Jing Zhang
Capital Medical University, China
Title: A preliminary study on multivariate prediction of seizure outcome after epilepsy surgery
Biography
Biography: Jing Zhang
Abstract
Surgical outcomes of epilepsy surgery vary across patients, and clinicians need to estimate possible outcomes before surgery. The aim of this study was to identify predictors of seizure outcome one year after surgery for patients with drug-resistant epilepsy. Twenty-three patients with Temporal Lobe Epilepsy (TLE) who underwent surgery were included in the study. Their demographical information, seizure history, findings of EEG and neuro-imaging tests (mainly Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS), intracranial EEG (icEEG) findings, seizure outcome and pathological findings were reviewed. Bi-variate analyses were performed to examine the uni-variate association of each variable with the outcome and exclude the most insignificant ones. The remaining data were randomly assigned to the training and test sets and three multivariate analysis approaches (Logistic Regression (LR), Linear Discriminant Analysis (LDA) and Artificial Neural Network (ANN)) were performed repetitively. Model performance was compared using Receiver-Operating Characteristic (ROC) analysis. Re-sampling the data to the training and test sets resulted in large variations in the classification accuracies of each multivariate approach. The ROC results indicated that the medium classification performances were moderate. Important outcome predictors identified included EEG lateralization score, icEEG lateralization score and the presence of Hippocampal Sclerosis (HS). The results suggested that multivariate models could predict seizure outcome after TLE surgery with moderate accuracy. Further studies are needed to improve prediction accuracy and identify reliable predictors of seizure outcome.